Thrombophilia or thrombophobia : clinical implications of recently identified thrombophilic disorders

There is growing evidence that venous thromboembolism often results from an interaction between various genetic and/or exogenous risk factors.
An increasing number of thrombophilic disorders has been identified, like inherited resistance to activated protein C (APC) due to factor V Leiden, and the prothrombin G20210A gene (factor II) mutation. Factor VLeiden is found in about 20% of consecutive patients with venous thromboembolism and in 50% of selected patients, the factor II mutation in 3% and 18% of these patients, respectively.
This thesis mainly deals with the clinical expression of factor V Leiden and the factor II mutation, either in the presence or absence of concomitant genetic or exogenous risk factors. It further focuses on acquired APC resistance in conditions that are known as risk factors for venous thromboembolism, particularly the use of oral contraceptives, pregnancy and major surgery.

	titlepages/contents
	chapter 1
	chapter 2
	chapter 3
	chapter 4
	chapter 5
	chapter 6
	chapter 7
	chapter 8
	chapter 9
	chapter 10
	chapter 11
	chapter 12
	chapter 13
	list of coauthors
	thesis

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