Receptors for IgG in systemic autoimmune disease

Functional polymorphisms in receptors for IgG (FcyR), affecting IgG binding, were first described in 1983, when a clear non-responder population was identified in the mitogenic effect on T cells of mouse IgG1 anti-CD3 antibodies (1). In the following years, our knowledge of structural diversity and heterogeneity in FcyR increased substantially, and clinical consequences of this variety became apparent (2,3). With the development of single and multiple Fc receptor deficient mice in the past decade, our view on Fc receptor interactions in the inflammatory response changed markedly (4, Chapter 1). More recent findings force us to revise our view on the involvement of FcyR polymorphisms in this response as well (Chapter 9).
Zie: Summary

Samenvatting

Meer informatie in de catalogus
Meer informatie in Picarta