Structure and mechanism of an integral membrane enzyme, outer membrane phospholipase A from Escherichia coli

All living organisms consist of cells, which are surrounded by membranes. These membranes are generally made up by phospholipids and membrane proteins. The membranes function as a barrier and allow cells to acquire a specific chemical environment, which is essential for the correct functioning of the organism.
This thesis describes the structure determination of the Outer Membrane Phospholipase A (OMPLA) from the outer membrane of the Escherichia coli bacterium. This integral membrane enzyme hydrolyses the phospholipids that compose the membrane. Due to this hydrolysis the membrane becomes more permeable.

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