Staphylococcus aureus and T cell activation in Wegener's granulomatosis.

Wegener's granulomatosis (WG) is a form of systemic vasculitis which, although well studied, still constitutes a black box with respect to its pathogenesis and - physiology. The complexity of the disease is partly due to the fact that autoimmune phenomena, among which the most characteristic is the presence of autoantibodies to neutrophil enzymes (ANCA), can be observed alongside clinical features such as necrotizing vasculitis, granuloma formation in the upper and lower respiratory tract and glomerulonephritis. However, evidence for the causal link between these phenomena is still circumstantial, despite efforts to demonstrate notably the contribution of ANCA to vascular and glomerular lesions. ...

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