The effects of factor VIII substitution on the immune system in multitransfused HIV negative haemophilia A patients

The transmission of the human immunodeficiency virus (HIV) by bloodproducts was a disastrous complication of substitution therapy for haemophilia A. Introduction of viral inactivation procedures provided effective methods to prevent HIV seroconversion. Nevertheless, hepatitis C virus (HCV) appeared not to be completely inactivated and administration of factor VIII concentrates showed to be associated with immune abnormalities in HIV negative heamophilia A patients. ...

Zie: Summary and conclusions

Summary and conclusion

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