Host immunity against secondary cytomegalovirus infections. Immunological and genetic studies in kidney transplant candidates and recipients.

Cytomegalovirus (CMV) infections are a major cause of morbidity and even mortality in immunocompromised hosts such as transplant recipients and patients with the Acquired Immunodeficiency Syndrome (AIDS). CMV-seronegative transplant recipients can largely be protect against primary CMV infections by using blood products and grafts from seronegative donors.
Cytomegalovirus has the capacity to establish a latent infection after a primary infection. An intact host cellular immunity is important for keeping CMV in latency. Reactivation of latent CMV can be achieved by affecting the immune system with immunosuppressive drugs of allogeneic stimuli. ...

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Summary and conclusions

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