Clinical and diagnostic features of amyloidosis

The term amyloidosis should be used in a generic sense and is applied to a family of diseases, which have as their common denominator organ function loss due to the extracellular deposition of a fibrillar protein with a B-pleated sheet conformation. This molecular structure of the fibrils in
amyloid deposits is considered to be responsible for their staining properties with Congo red and their relative resistance to proteolysis and solubilization. ...

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Summary

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