Microvascular and immunological studies in Raynaud's phenomenon.

The purpose of this thesis was to investigate the diagnostic significance of microvascular abnormalities - as observed in the nailfold - in patients with RP with respect to the presence or development of a connective tissue disease. In addition, we investigated whether the observed abnormalities were an expression of widespread microvascular organ disease. Finally, we studied the relationship between antibodies to nucleoribonucleoprotein (nRNP) and disease activity in a particular group of patients with RP characterized by the presence of these antibodies, both from a diagnostic and an immunoregulatory point of view. ...

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Summary and general discussion

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