Dissertations: Faculty of Mathematics and Natural Sciences http://dissertations.ub.rug.nl/ Dissertations RUG nl_NL Metastates, non-Gibbsianness and Phase Transitions: a stroll through statistical mechanics No description abstract http://irs.ub.rug.nl/ppn/339773758 Wed, 01 Feb 12 00:00:00 +0100 Molecule diffusion in bacteria and consequences of osmotic stress No description abstract http://irs.ub.rug.nl/ppn/339545690 Sat, 07 Jan 12 00:00:00 +0100 Sleep loss, brain vulnerability and psychopathology No description abstract http://irs.ub.rug.nl/ppn/33959683X Sat, 04 Feb 12 00:00:00 +0100 Modeling variability and integration of architectural patterns No description abstract http://irs.ub.rug.nl/ppn/339597321 Sat, 28 Jan 12 00:00:00 +0100 Novel approaches for the redesign of flavoprotein Oxidases No description abstract http://irs.ub.rug.nl/ppn/339493224 Sat, 14 Jan 12 00:00:00 +0100 Two-length-scale multiblock copolymer self-assembly: theoretical investigations and computer simulations No description abstract http://irs.ub.rug.nl/ppn/339845007 Fri, 14 Dec 12 00:00:00 +0100 Re-­direction of Interferon Gamma and its signaling moiety: New options for the therapy of chronic diseases No description abstract http://irs.ub.rug.nl/ppn/339772913 Sat, 28 Jan 12 00:00:00 +0100 Cognitive models of decision making : why precision matters No description abstract http://irs.ub.rug.nl/ppn/339436433 Sat, 21 Apr 12 00:00:00 +0200 Dynamics of Singlet and Triplet Excitons in Organic Semiconductors No description abstract http://irs.ub.rug.nl/ppn/339429771 Mon, 16 Jan 12 00:00:00 +0100 Fullerene bisadduct for organic photovoltaics No description abstract http://irs.ub.rug.nl/ppn/339436069 Sat, 21 Jan 12 00:00:00 +0100 Multiscale modelling of deformation and fracture in metal foams No description abstract http://irs.ub.rug.nl/ppn/339582928 Sat, 21 Jan 12 00:00:00 +0100 Revealing the light-harvesting properties of Photosystem I No description abstract http://irs.ub.rug.nl/ppn/339583398 Sat, 21 Jan 12 00:00:00 +0100 Risk assessment of antiepileptic drugs in pregnancy No description abstract http://irs.ub.rug.nl/ppn/339243252 Wed, 04 Jan 12 00:00:00 +0100 Cell-specific delivery of protein kinase inhibitors to the fibrotic liver No description abstract http://irs.ub.rug.nl/ppn/339160772 Sat, 07 Jan 12 00:00:00 +0100 Digital Pulse-Shape analysis and controls for advanced detector systems No description abstract http://irs.ub.rug.nl/ppn/339548215 Tue, 10 Jan 12 00:00:00 +0100 Structural and functional features of GltS of Escherichia coli No description abstract http://irs.ub.rug.nl/ppn/339530774 Mon, 09 Jan 12 00:00:00 +0100 Robust and applicable handwriting biometrics No description abstract http://irs.ub.rug.nl/ppn/339130628 Mon, 12 Dec 11 00:00:00 +0100 Hows and whys of left and right : ontogeny of lateralization and its functional relevance No description abstract http://irs.ub.rug.nl/ppn/339530405 Sat, 07 Jan 12 00:00:00 +0100 Health economics of new and under-used vaccines in developing countries: state-of-the-art analyses for hepatitis B and rotavirus in Vietnam No description abstract http://irs.ub.rug.nl/ppn/339156988 Fri, 28 Jan 11 00:00:00 +0100 Over: "The law of uniform seniority" No description abstract http://irs.ub.rug.nl/ppn/040504581 Thu, 27 Oct 11 00:00:00 +0200 Dissipativity-based control of nonlinear power systems : applications to harmonic control and power factor compensation No description abstract http://irs.ub.rug.nl/ppn/338798404 Tue, 06 Dec 11 00:00:00 +0100 Multidrug resistence and its regulation in Enterococcus faecalis No description abstract http://irs.ub.rug.nl/ppn/338346597 Fri, 25 Nov 11 00:00:00 +0100 Visualization of dense line data No description abstract http://irs.ub.rug.nl/ppn/338810471 Sat, 10 Dec 11 00:00:00 +0100 Elliptic delsarte surfaces No description abstract http://irs.ub.rug.nl/ppn/339372087 Wed, 04 Jan 12 00:00:00 +0100 The distribution of mass within spiral galaxies : unique solutions from gas and stellar kinematics No description abstract http://irs.ub.rug.nl/ppn/339227109 Sun, 18 Dec 11 00:00:00 +0100 Natural diversity and catalytic mechanisms of ∆1- and ∆4 3-ketosteroid dehydrogenase enzymes from actinomycetal origin No description abstract http://irs.ub.rug.nl/ppn/338441573 Sat, 26 Nov 11 00:00:00 +0100 Galactic archaeology in and around the Milky Way No description abstract http://irs.ub.rug.nl/ppn/338804676 Sat, 10 Dec 11 00:00:00 +0100 Adaptive dissimilarity measures, dimension reduction and visualization No description abstract http://irs.ub.rug.nl/ppn/338811206 Sat, 17 Dec 11 00:00:00 +0100 The ecological and evolutionary consequences of brood sex ratio variation Sex allocation theory is successful in predicting sex ratio variation in some taxa, but often not in birds and mammals. An important reason may be that most theoretical models do not account for the complexities of avian and mammalian life-history. Radersma investigated the effect of manipulated brood sex ratios on long-term fitness benefits. Since offspring recruitment, parental survival and parental future fecundity were unaffected, there was stabilizing selection for producing brood sex ratios at parity. To gain insight in the underlying mechanism he focused on different aspects of the offspring’s first year. Brood sex ratio did not affect fledging behaviour, but there were some effects on social behaviour in winter, which did not correlate to fitness. As adults, individuals raised as the rare sex in a brood had larger tarsi than individuals of the abundant sex. This relationship was neither present in the nestling phase nor caused by selective disappearance. This suggests a sex-specific directional effect of brood sex ratio on the late development of the offspring, which potentially links brood sex ratio to fecundity. Stabilizing selection for brood sex ratios at parity might provide an explanation why sex allocation in birds and mammals is often subtle. Higher benefits for equal brood sex ratios counteract selection for facultative sex allocation to extreme values. http://irs.ub.rug.nl/ppn/338646280 Sat, 03 Dec 11 00:00:00 +0100 Physics of one-dimensional hybrids based on carbon nanotubes No description abstract http://irs.ub.rug.nl/ppn/338593284 Tue, 06 Dec 11 00:00:00 +0100 Thermal spin transport and spin transfer torque in ferromagnetic/non-magnetic nanoscale devices No description abstract http://irs.ub.rug.nl/ppn/338642560 Tue, 29 Nov 11 00:00:00 +0100 Applying dynamic Bayesian networks in transliteration detection and generation No description abstract http://irs.ub.rug.nl/ppn/338595783 Sat, 03 Dec 11 00:00:00 +0100 Exploring 3-ketosteroid 9a-hydroxylases of Rhodococcus rhodochrous DSM43269 : biochemical, physiological, molecular and structural characterization of a key enzyme in bacterial steroid degradation No description abstract http://irs.ub.rug.nl/ppn/338440712 Sat, 26 Nov 11 00:00:00 +0100 More than a transcription factor: SpoOA mediates phenotypic heterogeneity and controls replication in Bacillus subtilis No description abstract http://irs.ub.rug.nl/ppn/338443363 Sat, 19 Nov 11 00:00:00 +0100 Het constitutioneel familie-beeld bij de schizophrenie : een onderzoek naar de psychotische en karakterologische belasting en naar de wijze van overerven No description abstract http://irs.ub.rug.nl/ppn/040731243 Tue, 01 Nov 11 00:00:00 +0100 Hard times in paradise? : oxidative status, physiology and fitness in the tropical Seychelles warbler No description abstract http://irs.ub.rug.nl/ppn/338463518 Sat, 12 Nov 11 00:00:00 +0100 Synthesis and bioactivity of novel histone acetylation inhibitors : potential new drugs for treatment of cancer and inflammation There is an increasing interest in histone acetyltransferases (HATs) as new therapeutic targets for treatment of diseases like, for example, inflammation and cancer. However, only few small and cell-permeable molecule inhibitors of HATs are currently available. The work described in this thesis focuses on the synthesis and biological evaluation of novel HAT inhibitors. The major challenge is to find potent and selective HAT inhibitors that show biological activity in cells. In the first part of this thesis we report the design and synthesis of potent isothiazolone-based inhibitors of the recombinant HAT PCAF, which are also cytotoxic for different cancer cell lines. Moreover, we elucidate the chemical reactivity of isothiazolones derivatives showing that isothiazolones might find applications in activity-based protein profiling studies. The second part of this thesis describes the development of novel HAT inhibitors using the natural product anacardic acid (AA) as starting point. Using a combination of molecular design, organic synthesis and enzyme inhibition studies, we develop several novel compounds that are selective inhibitors of the recombinant HAT Tip60 in comparison with the HATs PCAF and p300. Furthermore, we identify a new AA derivative that shows a twofold improved potency for inhibition of histone H4 acetylation in cell-based studies. In conclusion, the work described in this thesis provides new chemical tools for pharmacological studies to validate HATs inhibitors as potential new drugs for treatment of cancer and inflammation. http://irs.ub.rug.nl/ppn/339132833 Sat, 10 Dec 11 00:00:00 +0100 Organic field-effect transistors for sensing applications No description abstract http://irs.ub.rug.nl/ppn/338773126 Sat, 26 Nov 11 00:00:00 +0100 The origin of stars: Tales from the unexpected in extreme environments No description abstract http://irs.ub.rug.nl/ppn/338588906 Tue, 22 Nov 11 00:00:00 +0100 Über die Torsion des Stengels von Psilotum Bernhardi : Beiträge zur Kenntnis der autonomen Bewegungen No description abstract http://irs.ub.rug.nl/ppn/036067083 Fri, 07 Oct 11 00:00:00 +0200 Protein engineering of esterases: climbing the protein fitness landscape No description abstract http://irs.ub.rug.nl/ppn/338293442 Wed, 26 Oct 11 00:00:00 +0200 Mining, brushing and flushing : feeding mechanism, turbative activity and behavioural energetics of the endobenthic thalassinid shrimp Callianassa subterranea No description abstract http://irs.ub.rug.nl/ppn/161241506 Mon, 24 Oct 11 00:00:00 +0200 Chiral Lewis acid catalyzed Diels-Alder reactions No description abstract http://irs.ub.rug.nl/ppn/148534457 Mon, 24 Oct 11 00:00:00 +0200 Extraction and transport of ion beams from an ECR ion source No description abstract http://irs.ub.rug.nl/ppn/338298649 Sat, 12 Nov 11 00:00:00 +0100 Developing suitable polymer semiconducrors for the application in BioFETs No description abstract http://irs.ub.rug.nl/ppn/338233695 Sat, 19 Nov 11 00:00:00 +0100 Buckling-driven self-formation of microchannels No description abstract http://irs.ub.rug.nl/ppn/338298703 Wed, 12 Oct 11 00:00:00 +0200 Magnetic and spectroscopic studies of iron and manganese complexes : from molecular materials to catalysis No description abstract http://irs.ub.rug.nl/ppn/338203435 Mon, 24 Oct 11 00:00:00 +0200 Electrochemistry in the mimicry of oxidative drug metabolism No description abstract http://irs.ub.rug.nl/ppn/338115862 Tue, 25 Oct 11 00:00:00 +0200 Song in space : the effects of song structure and singer location on territorial behavior in nightingales No description abstract http://irs.ub.rug.nl/ppn/338111107 Wed, 12 Oct 11 00:00:00 +0200 Regularising amorphous Peer-to-Peer networks with overlay grids generated locally No description abstract http://irs.ub.rug.nl/ppn/338093761 Wed, 12 Oct 11 00:00:00 +0200