Dissertations: Faculty of Medical Sciences http://dissertations.ub.rug.nl/ Dissertations RUG nl_NL Aspects of long-term use of antipsychotic drugs on an off-label base in individuals with intellectual disability No description abstract http://irs.ub.rug.nl/ppn/362742588 Tue, 18 Jun 13 00:00:00 +0200 Lifestyle, the next target for intervention in renal transplant recipients No description abstract http://irs.ub.rug.nl/ppn/362748187 Mon, 10 Jun 13 00:00:00 +0200 Renal regenerative medicine : bioengineering of cell-based membranes and anti-inflammatory drug delivery No description abstract http://irs.ub.rug.nl/ppn/362747938 Fri, 07 Jun 13 00:00:00 +0200 Improvement of influenza vaccines by using a saponin-derived adjuvant No description abstract http://irs.ub.rug.nl/ppn/357806174 Fri, 07 Jun 13 00:00:00 +0200 Modulation of Microglial Activity No description abstract http://irs.ub.rug.nl/ppn/357805550 Thu, 06 Jun 13 00:00:00 +0200 Youth subcultures and problem behaviours in Slovakia: Hip-Hop, Techno-scene, Metal, Punk, Skinheads and Roma No description abstract http://irs.ub.rug.nl/ppn/357978870 Tue, 04 Jun 13 00:00:00 +0200 Physical activity and overweight in young children No description abstract http://irs.ub.rug.nl/ppn/362758026 Tue, 25 Jun 13 00:00:00 +0200 Comorbidity in heart failure No description abstract http://irs.ub.rug.nl/ppn/357967003 Thu, 30 May 13 00:00:00 +0200 Posttraumatic stress following pregnancy and childbirth No description abstract http://irs.ub.rug.nl/ppn/357967046 Wed, 26 Jun 13 00:00:00 +0200 Regional mortality in Slovakia : socioeconomic indicators and ethnicity No description abstract http://irs.ub.rug.nl/ppn/357966791 Fri, 24 May 13 00:00:00 +0200 The role of stress in the etiology of asthma No description abstract http://irs.ub.rug.nl/ppn/357473175 Wed, 29 May 13 00:00:00 +0200 Renal risk markers and patient prognosis in chronic kidney disease No description abstract http://irs.ub.rug.nl/ppn/357475917 Tue, 28 May 13 00:00:00 +0200 Early motor repertoire of infants at risk No description abstract http://irs.ub.rug.nl/ppn/357499913 Tue, 28 May 13 00:00:00 +0200 Sports and amputation No description abstract http://irs.ub.rug.nl/ppn/357799194 Mon, 27 May 13 00:00:00 +0200 Progression in melanoma: considerations and implictions in dissecting nodal fields No description abstract http://irs.ub.rug.nl/ppn/357577515 Fri, 24 May 13 00:00:00 +0200 Prevention of recurrent sickness absence in workers with common mental disorders No description abstract http://irs.ub.rug.nl/ppn/357537246 Thu, 23 May 13 00:00:00 +0200 Thiamine, fasting and the kidney No description abstract http://irs.ub.rug.nl/ppn/357529669 Wed, 12 Jun 13 00:00:00 +0200 Immunologic aspects of ovarian cancer No description abstract http://irs.ub.rug.nl/ppn/357529537 Mon, 20 May 13 00:00:00 +0200 Determinants of adherence to inhaled corticosteroids in children with asthma No description abstract http://irs.ub.rug.nl/ppn/357536738 Tue, 21 May 13 00:00:00 +0200 Understanding HDL function : studies in preclinical models and patients No description abstract http://irs.ub.rug.nl/ppn/357536592 Thu, 23 May 13 00:00:00 +0200 Thoracic masses : from chest radiography and ultrasound guided biopsies to molecular biology No description abstract http://irs.ub.rug.nl/ppn/357537408 Tue, 21 May 13 00:00:00 +0200 Disability in patients with chronic neck pain : the clinimetric properties of instruments No description abstract http://irs.ub.rug.nl/ppn/357415108 Thu, 16 May 13 00:00:00 +0200 Technical skills, the key to succes? A study on talent development and selection of youth soccer players No description abstract http://irs.ub.rug.nl/ppn/357528298 Tue, 07 May 13 00:00:00 +0200 The early detection of psychosocial problems in children aged 0 to 6 years by Dutch preventive child healthcare: professionals and their tools No description abstract http://irs.ub.rug.nl/ppn/357317459 Wed, 15 May 13 00:00:00 +0200 New targets in cardiovascular imaging No description abstract http://irs.ub.rug.nl/ppn/357376994 Wed, 15 May 13 00:00:00 +0200 COMMD1: a modulator of immunity and NF-kB activity No description abstract http://irs.ub.rug.nl/ppn/357527534 Wed, 22 May 13 00:00:00 +0200 Soft-tissue sarcomas of the extremities: aspects of survival and long-term results of isolated limb perfusion No description abstract http://irs.ub.rug.nl/ppn/357527240 Mon, 13 May 13 00:00:00 +0200 MicroRNA profiling in B cell non-Hodgkin Lymphoma : focus on the role of MYC No description abstract http://irs.ub.rug.nl/ppn/357529103 Mon, 13 May 13 00:00:00 +0200 Prognostic factors of functional outcome in acute ischemic stroke No description abstract http://irs.ub.rug.nl/ppn/357532465 Mon, 13 May 13 00:00:00 +0200 Evaluation of Crohn's disease activity: an integrated imaging approach No description abstract http://irs.ub.rug.nl/ppn/357529170 Mon, 13 May 13 00:00:00 +0200 Physical activity in patients with Chronic Obstructive Pulmonary Disease No description abstract http://irs.ub.rug.nl/ppn/357312643 Thu, 02 May 13 00:00:00 +0200 The biology of human hematopoietic stem and progenitor cells in acute myeloid leukemia, aging and autologous transplantation No description abstract http://irs.ub.rug.nl/ppn/357306724 Wed, 29 May 13 00:00:00 +0200 Imaging in dermal fillers No description abstract http://irs.ub.rug.nl/ppn/357204204 Fri, 03 May 13 00:00:00 +0200 Novel markers in chronic heart failure No description abstract http://irs.ub.rug.nl/ppn/357285751 Tue, 30 Apr 13 00:00:00 +0200 Adolescents at risk for social and test anxiety. Who are at risk and how can we help? No description abstract http://irs.ub.rug.nl/ppn/357239237 Wed, 01 May 13 00:00:00 +0200 Assessment of the biliary tree No description abstract http://irs.ub.rug.nl/ppn/357148592 Thu, 25 Apr 13 00:00:00 +0200 Music therapy for dementia : the effect of music therapy in reducing behavioural problems in elderly people with dementia No description abstract http://irs.ub.rug.nl/ppn/357472667 Tue, 23 Apr 13 00:00:00 +0200 Een methode voor kwantitatieve bepaling van immunoglobulinen met enkele klinische toepassingen No description abstract http://irs.ub.rug.nl/ppn/83787195 Wed, 13 Mar 13 00:00:00 +0100 Aortasclerose; Bevindingen bij een bevolkingsonderzoek te Zutphen No description abstract http://irs.ub.rug.nl/ppn/840198892 Wed, 06 Mar 13 00:00:00 +0100 Experimentele onderzoekingen over immuno-tolerantie No description abstract http://irs.ub.rug.nl/ppn/840782411 Wed, 06 Mar 13 00:00:00 +0100 Enkele toepassingen van telemetrie in de cardiologie. No description abstract http://irs.ub.rug.nl/ppn/833614924 Tue, 29 Jan 13 00:00:00 +0100 Registratie van ascorbinaatverdunningscurven en van veranderingen in Po2 en bloedstroomsnelheid met onbekende gepolariseerde Pt-elektrodes. No description abstract http://irs.ub.rug.nl/ppn/831952520 Tue, 29 Jan 13 00:00:00 +0100 Epidemiology of chronic non-specific lung disease (chronic bronchitits); a critical analysis of three surveys of CNSLD carried out in the Netherlands No description abstract http://irs.ub.rug.nl/ppn/830302239 Tue, 22 Jan 13 00:00:00 +0100 Oordeel en vooroordeel in psychiatrische diagnostiek No description abstract http://irs.ub.rug.nl/ppn/83361455X Wed, 23 Jan 13 00:00:00 +0100 Self-monitoring of blood glucose in insulin-treated patients with diabetes No description abstract http://irs.ub.rug.nl/ppn/356625575 Mon, 22 Apr 13 00:00:00 +0200 Immature dengue virus : functional properties and potential contribution to disease No description abstract http://irs.ub.rug.nl/ppn/356609588 Thu, 18 Apr 13 00:00:00 +0200 Long-term outcomes of stroke rehabilitation: patients and informal caregivers No description abstract http://irs.ub.rug.nl/ppn/357074343 Thu, 18 Apr 13 00:00:00 +0200 Development of moderately preterm-born children Children born 4-8 weeks prematurely have a higher risk of developmental problems than previously presumed. This is one of the findings in the Pinkeltje study, set up by UMCG paediatrician and neonatologist Jorien Kerstjens. ‘Some seven percent of all children in the Netherlands are born prematurely and the majority of them (70-85%) fall into this category,’ says Kerstjens. ‘It is a “forgotten” group. Unlike children born more than eight weeks prematurely (the “real” premature infants), paediatrics does not provide follow-up monitoring during their development.’ In view of the fact that 35% of brain development takes place in the final phase of pregnancy, Kerstjens is arguing for greater awareness of the risk of developmental problems in moderately preterm-born children. She will be awarded a PhD by the University of Groningen on 13 May 2013. Kerstjens compared the development of children born moderately prematurely with that of children born full term and very prematurely (pregnancy of less than 32 weeks). At four years of age, she found developmental problems in 8.3% of the moderately preterm-born children, which is double the percentage found in children born full term. Developmental problems were evident in 14.9% of the seriously preterm-born children. By the age of seven, the moderately preterm-born children were scoring lower than children born full term for IQ, the development of visual-spatial skills (such as doing jigsaws), attention span and selective focusing on main issues. ‘Up until now, it was generally assumed that moderately preterm-born children would develop normally, but my research shows that some of these children show clear signs of long-term developmental problems’, says Kerstjens. Exponential The more prematurely infants are born, the higher the risk of developmental problems, concludes Kerstjens. ‘We think this is because the most important part of brain development takes place in the third trimester of pregnancy. Many premature infants have also experienced other problems relating to the placenta; they are put into incubators immediately after birth, are fed differently and exposed to different stimuli than if they had been carried to full term. This causes their brains to develop differently from children born full term.’ Kerstjens would like to see more attention paid to these risks when deciding whether or not to deliver an infant before term. Factors A number of well-known factors increase the risks of premature labour and developmental problems in moderately preterm-born children. Kerstjens cites smoking during pregnancy and obesity on the part of the mother. ‘Multiple pregnancies also tend to be shorter. Fertility treatment such as IVF often leads to multiple births. Indirectly, my research seems to be advising women not to wait too long before getting pregnant,’ says Kerstjens. Social importance According to Kerstjens, we are currently putting a lot of effort into monitoring and helping children born more than eight weeks prematurely. ‘This is obviously important, but we should be doing more for the group of moderately preterm-born children too. The social importance of monitoring and helping this group should not be underestimated. It’s actually more important than helping the group of very preterm-born children.’ In absolute terms, the group of moderately preterm-born 4-year-olds with retarded development in the Netherlands is probably twice as large as the group of more seriously preterm-born 4-year-olds with developmental problems. Kerstjens thinks that helping these children during the first four years of their lives may improve their opportunities in the future. She is also predicting more attention world-wide for moderately preterm-born children. http://irs.ub.rug.nl/ppn/356383326 Thu, 18 Apr 13 00:00:00 +0200 Pelvic high-grade serous carcinoma in BRCA1 and BRCA2 mutation carriers : carcinogenesis and early diagnosis No description abstract http://irs.ub.rug.nl/ppn/357088972 Thu, 18 Apr 13 00:00:00 +0200 Molecular imaging of tumor characteristics to support targeted cancer therapies: a preclinical focus on HER2, HER3, c-MET, IGF-1R and VEGF-A imaging No description abstract http://irs.ub.rug.nl/ppn/35659887X Thu, 18 Apr 13 00:00:00 +0200